| Date | Player | Hits | |
| 04/27/1876 | Patrick O'Hanlon | 6 Hits in 7 AB, 3 RBI versus New York while playing for Cincinnati | |
| 05/16/1876 | Al Lowther | 6 Hits in 7 AB, 6 RBI versus St. Louis while playing for Chicago | |
| 07/19/1879 | Frank Trease | 6 Hits in 7 AB, 2 RBI versus Milwaukee while playing for Chicago | |
| 07/31/1879 | Ken Burris | 6 Hits in 6 AB, 6 RBI versus Milwaukee while playing for New York | |
| 09/18/1879 | Art Gordon | 6 Hits in 6 AB, 4 RBI versus Milwaukee while playing for Cleveland | |
| 09/10/1881 | Tommy Allen | 6 Hits in 7 AB, 1 HR and 4 RBI versus Philadelphia while playing for Providence | |
| 06/26/1882 | Joe Owns | 6 Hits in 7 AB, 3 RBI versus Boston while playing for Baltimore | |
| 06/29/1882 | James Eubanks | 6 Hits in 6 AB, 2 RBI versus Cleveland while playing for Philadelphia | |
| 05/15/1884 | Steve Airington | 6 Hits in 6 AB, 2 RBI versus Providence while playing for Brooklyn | |
| 07/22/1884 | Dave Grigsby | 6 Hits in 7 AB, 1 RBI versus Providence while playing for Philadelphia | |
| 08/11/1884 | Willie Davis | 6 Hits in 7 AB, 2 RBI versus Brooklyn while playing for Boston | |
| 05/16/1887 | Edwin Manna | 6 Hits in 7 AB, 2 RBI versus Washington while playing for Buffalo | |
| 07/16/1889 | Frank Booker | 6 Hits in 6 AB, 4 RBI versus Pittsburgh while playing for Chicago | |
| 07/03/1890 | Daniel Gladney | 6 Hits in 7 AB, 3 RBI versus Pittsburgh while playing for Washington | |
| 07/02/1893 | Elmer Selders | 6 Hits in 6 AB, 1 HR and 2 RBI versus St. Louis while playing for Pittsburgh | |
| 05/09/1895 | Johnny Terrell | 6 Hits in 7 AB, 5 RBI versus Toronto while playing for Chicago | |
| 05/27/1895 | Martin Thomas | 6 Hits in 6 AB, 3 RBI versus Boston while playing for Philadelphia | |
| 09/12/1895 | Calvin Kidd | 6 Hits in 7 AB, 4 RBI versus Brooklyn while playing for Chicago | |
| 09/01/1896 | Lewis Webster | 6 Hits in 6 AB, 0 RBI versus Baltimore while playing for Cleveland | |
| 07/09/1897 | John Jones | 6 Hits in 6 AB, 3 RBI versus Detroit while playing for Boston | |
| 09/25/1897 | Sam Mills | 6 Hits in 7 AB, 3 RBI versus Chicago while playing for Cleveland | |
| 06/08/1899 | Henry Turner | 6 Hits in 7 AB, 4 RBI versus Baltimore while playing for Cleveland | |
| 06/14/1901 | Thomas Watkins | 6 Hits in 7 AB, 1 RBI versus Brooklyn while playing for Toronto | |
| 08/20/1906 | Gil Hice | 6 Hits in 6 AB, 0 RBI versus Montreal while playing for Chicago | |
| 07/13/1907 | John Cardi | 6 Hits in 6 AB, 3 RBI versus Philadelphia while playing for Brooklyn | |
| 05/22/1911 | Billy Joe Davis | 6 Hits in 6 AB, 4 RBI versus Pittsburgh while playing for Detroit | |
| 07/12/1911 | David Lucca | 6 Hits in 6 AB, 1 RBI versus Montreal while playing for Philadelphia | |
| 04/17/1915 | Jim Broudy | 6 Hits in 6 AB, 2 RBI versus Montreal while playing for New York | |
| 08/25/1918 | Art Manos | 6 Hits in 9 AB, 1 RBI versus Washington while playing for Chicago | |
| 04/24/1919 | Jason Hopkins | 6 Hits in 8 AB, 3 RBI versus Chicago while playing for St. Louis | |
| 08/30/1919 | Frank Betts | 6 Hits in 7 AB, 2 RBI versus Chicago while playing for Philadelphia | |
| 09/21/1921 | Edwin Segovia | 6 Hits in 6 AB, 1 HR and 6 RBI versus Chicago while playing for Montreal | |
| 04/16/1924 | Cy Lynch | 6 Hits in 6 AB, 1 HR and 9 RBI versus New York while playing for Detroit | |
| 07/26/1925 | Lou Cox | 6 Hits in 7 AB, 3 RBI versus Montreal while playing for Brooklyn | |
| 08/26/1926 | Andy Stoddard | 7 Hits in 7 AB, 4 RBI versus Chicago while playing for Baltimore | |
| 04/21/1928 | Doc Nowack | 6 Hits in 6 AB, 1 RBI versus Philadelphia while playing for Pittsburgh | |
| 09/20/1929 | Frank Vance | 6 Hits in 6 AB, 6 RBI versus Boston while playing for Detroit | |
| 07/30/1930 | Johnny Allen | 6 Hits in 6 AB, 3 RBI versus Washington while playing for Pittsburgh | |
| 08/01/1930 | Speed Davis | 6 Hits in 6 AB, 1 HR and 5 RBI versus Brooklyn while playing for New York | |
| 05/06/1931 | Red Williams | 6 Hits in 7 AB, 0 RBI versus Baltimore while playing for New York | |
| 06/05/1931 | Hank Bullock | 6 Hits in 6 AB, 1 RBI versus New York while playing for Washington | |
| 05/28/1932 | Moxie Pidgeon | 6 Hits in 6 AB, 1 HR and 5 RBI versus Chicago while playing for Cleveland | |
| 06/07/1932 | Andy Carter | 6 Hits in 7 AB, 1 RBI versus Chicago while playing for Washington | |
| 07/02/1932 | Arnold Bower | 6 Hits in 6 AB, 2 RBI versus Cleveland while playing for Chicago | |
| 08/28/1933 | Cy Cox | 6 Hits in 6 AB, 4 RBI versus Washington while playing for Philadelphia | |
| 05/14/1934 | Mike Mason | 6 Hits in 6 AB, 0 RBI versus Toronto while playing for New York | |
| 08/27/1934 | Fred McCormick | 6 Hits in 6 AB, 1 HR and 5 RBI versus Washington while playing for St. Louis | |
| 08/17/1935 | Max Morris | 6 Hits in 6 AB, 2 RBI versus Baltimore while playing for Cleveland | |
| 06/12/1937 | Fred McCormick | 6 Hits in 6 AB, 0 RBI versus Philadelphia while playing for St. Louis | |
| 09/20/1937 | Wally Flowers | 6 Hits in 6 AB, 5 RBI versus Chicago while playing for Washington | |
| 06/03/1938 | Pete Layton | 6 Hits in 7 AB, 3 RBI versus Washington while playing for Chicago | |
| 06/15/1941 | Ben Richardson | 6 Hits in 6 AB, 6 RBI versus Cleveland while playing for Montreal | |
| 09/18/1943 | Aart MacDonald | 6 Hits in 7 AB, 1 HR and 2 RBI versus New York while playing for Detroit | |
| 09/09/1944 | Sid Williams | 6 Hits in 8 AB, 2 HR and 2 RBI versus New York while playing for Detroit | |
| 07/31/1945 | Johnny McDowell | 6 Hits in 6 AB, 0 RBI versus Washington while playing for Pittsburgh | |
| 05/26/1946 | Sal Pestilli | 6 Hits in 6 AB, 1 HR and 1 RBI versus Chicago while playing for New York | |
| 06/16/1946 | Bob Montgomery | 7 Hits in 7 AB, 1 HR and 2 RBI versus Pittsburgh while playing for Detroit | |
| 05/25/1948 | Jackie Garner | 6 Hits in 9 AB, 2 RBI versus Detroit while playing for Washington | |
| 08/06/1948 | Ernie Campbell | 6 Hits in 6 AB, 1 RBI versus St. Louis while playing for Pittsburgh | |
| 06/19/1951 | Rip Lee | 6 Hits in 6 AB, 3 RBI versus New York while playing for Philadelphia | |
| 07/08/1951 | Les Cunha | 6 Hits in 6 AB, 1 HR and 1 RBI versus Toronto while playing for Philadelphia | |
| 08/12/1953 | Ed Bloom | 6 Hits in 7 AB, 3 RBI versus Detroit while playing for Chicago | |
| 07/22/1954 | George Rutter | 6 Hits in 7 AB, 3 HR and 7 RBI versus Toronto while playing for San Francisco | |
| 08/08/1958 | Eddie Dickey | 6 Hits in 8 AB, 1 HR and 3 RBI versus Kansas City while playing for Los Angeles | |
| 08/16/1958 | Ralph Hanson | 6 Hits in 6 AB, 1 RBI versus Cincinnati while playing for Montreal | |
| 06/28/1960 | John Kingsbury | 6 Hits in 7 AB, 2 RBI versus Montreal while playing for San Francisco | |
| 06/21/1961 | Virgil Ewing | 6 Hits in 10 AB, 1 HR and 1 RBI versus Kansas City while playing for Los Angeles | |
| 06/16/1962 | Cecil Gregg | 6 Hits in 6 AB, 6 RBI versus Boston while playing for Detroit | |
| 07/17/1963 | Bob G. Murphy | 6 Hits in 6 AB, 0 RBI versus Los Angeles while playing for Philadelphia | |
| 08/18/1963 | Chick Reed | 6 Hits in 6 AB, 1 HR and 5 RBI versus San Francisco while playing for Toronto | |
| 09/27/1963 | Charlie Sax | 6 Hits in 6 AB, 3 RBI versus Cleveland while playing for Los Angeles | |
| 09/30/1968 | Pat Davis | 6 Hits in 8 AB, 1 HR and 2 RBI versus Cincinnati while playing for Seattle | |
| 08/15/1969 | Orlando Benitez | 6 Hits in 6 AB, 1 HR and 4 RBI versus Seattle while playing for Cleveland | |
| 08/19/1970 | George James | 6 Hits in 6 AB, 0 RBI versus Baltimore while playing for New York | |
| 07/09/1972 | Johnny Kelley | 6 Hits in 7 AB, 1 HR and 2 RBI versus Baltimore while playing for St. Louis | |
| 05/23/1973 | Ike Barnett | 6 Hits in 6 AB, 3 RBI versus New York while playing for Baltimore | |
| 05/27/1974 | Julio Castaneda | 6 Hits in 6 AB, 1 HR and 5 RBI versus New York while playing for Minneapolis | |
| 09/09/1974 | Bobby Garrison | 6 Hits in 6 AB, 1 HR and 2 RBI versus Chicago while playing for Los Angeles | |