The AFA fielded 18 teams in 1922 and the uneven scheduling led to a bit of controversy at season's end when the league office found itself with a dilemma: the first-year Evansville Lions posted a 10-1-0 mark while the established Pittsburgh Pros went 10-2-0. The Pros played what was generally considered a "tougher" schedule and sentiment was high that the championship title be awarded to them. But the AFA office went with Evansville making the Lions the official AFA Champions, though Pittsburgh disputed the decision and many felt that the Pros were the "real champs" of the 1922 season.

After a moderately successful debut campaign, the American Football Association held its first annual meeting, again at Jack Kristich's restaurant in Fort Wayne, Indiana. Among the agenda items was choosing a new president. with John "Ox" Oxendine, the star player/owner/coach of the Pittsburgh Pros unwilling (some said unable) to perform the duties necessary in that position. Oxendine, in fact, didn't even show up at the league meeting and his status was a bit of a question with rumors abounding that he wouldn't even play in 1921. To replace him, the group of owners selected one of their own - and their host - Jack Kristich. Kristich would prove an inspired choice even though at the time he "didn't seek and didn't even want the job" as he remembered years later. 

Among other things, the face of the league changed with new members joining, as the membership swelled to 21 teams. Among the rules put in place in Kristich's first year at the helm were a codification of the playing rules (they would mirror those of college foothall - for now), a rule that only games against other league members would count towards the title, and the weekly reporting of standings to make the champion more evident (there would be no playoffs). The rule about only league games counting would have repercussions for the independent operators whose teams would now find AFA clubs less willing to play them in what amounted to exhibition games as they would not help win the championship. These AFA vs Indy team matchups wouldn't disappear for years, but the new rule did hasten the demise of the independent pro teams that dotted the eastern and midwestern landscape.

On the field, Carl Boon's Chicago Wildcats proved to be the class of the league. The 'Cats posted a 9-1-1 mark, edging out the Akron Triangles whose 9-2-1 mark was just a bit worse. Buffalo (8-3-1) was third. The former Rochester club, owned by Rollie Barrell, had folded and Barrell moved his operation to Detroit. The new "Detroit Maroons" would prove to have staying power and though they initially posted a 4-2-0 mark (and got into trouble with the league for flouting the no-college-player rule - more on this below), the Maroons would go on to become one of the AFA's storied franchises. The Maroons were replaced in Rochester with a new entry - the Robins - who like their predecessors had trouble drawing fans, and played only five games.