| Date | Player | Strikeouts | |
| 05/14/1878 | Buster Scott | 15 K, 3 BB and 9.0 IP versus Detroit while playing for Brooklyn | |
| 07/27/1878 | Buster Scott | 16 K, 1 BB and 9.0 IP versus Detroit while playing for Brooklyn | |
| 07/31/1878 | Jim Cannon | 18 K, 0 BB and 9.0 IP versus Detroit while playing for Brooklyn | |
| 05/06/1879 | Billy Roberson | 15 K, 2 BB and 9.0 IP versus Milwaukee while playing for Brooklyn | |
| 05/22/1879 | Martin Tucker | 17 K, 0 BB and 9.0 IP versus Milwaukee while playing for Cleveland | |
| 06/14/1880 | Martin Tucker | 15 K, 0 BB and 9.0 IP versus Cleveland while playing for Philadelphia | |
| 06/16/1880 | Will Bullock | 16 K, 3 BB and 9.0 IP versus Brooklyn while playing for Philadelphia | |
| 06/26/1880 | Will Bullock | 15 K, 3 BB and 10.0 IP versus Brooklyn while playing for Philadelphia | |
| 06/04/1906 | Bill Temple | 15 K, 0 BB and 10.0 IP versus Boston while playing for Detroit | |
| 07/19/1907 | Ed Dunbar | 15 K, 3 BB and 11.1 IP versus Toronto while playing for New York | |
| 10/03/1907 | Pep McCormick | 17 K, 7 BB and 14.0 IP versus Chicago while playing for Philadelphia | |
| 05/04/1911 | Pete Dach | 15 K, 4 BB and 12.1 IP versus Baltimore while playing for Montreal | |
| 07/13/1912 | Tom Guarneri | 15 K, 3 BB and 9.0 IP versus Baltimore while playing for Chicago | |
